How Long Does Morphine Stay In Your System?

How long does Morphine stay in your system? Morphine is a commonly prescribed drug used to treat pain with fast-acting effects. Due to its fast action, this drug is a favorite among many people for acute pain treatment.

The ordinary effects of Morphine generally appear in about a few hours, but how does Morphine stay in your system? You can’t imagine. You should not use this drug without a medical prescription because it has several adverse effects, mainly addiction.

In case you are an addict of Morphine, you have to use a detox to clean out all traces of Morphine from your body.

Recovery from morphine addiction is possible, but you have to pay attention and note that addiction is physical and psychological, so you have to pay attention for recovery.

Let’s move to our topic, “How long does morphine stay in your system?”

What Is Morphine?

The most famous medication of the opioid drug family is Morphine. Morphine is a depressant along with painkillers, and it is derived from the opium poppy plant.

Its mechanism of action includes:

  • Slowing down of the nervous system
  • Reduction of neural activity
  • Decrease in cognitive function
  • Blockage of pain receptors in the human brain

This medication is prescribed by many physicians in certain conditions of operation, cancer treatment, and to control the pain of broken none, which may vary from moderate to severe.

Common Brand Names Of Morphine:

These are common brand names:

  • Oramorph SR
  • MS Contin
  • Kadian
  • Morphabond

The unique effects of Morphine include:

  • Pain control
  • Drowsiness
  • Feeling of well-being

Remember, it is too dangerous to use opioids without a prescription because addiction can cause many adverse effects if a person is at risk of addiction.

You should immediately ask your medical worker to prescribe an alternative painkiller if you think you are using this drug in large amounts.

How Long Does Morphine Take To Show Effects?

There is no pet answer to this question because morphine dosage varies from person to person to help with pain. But there are some factors which influence its time to show effects:

  • The last date of opioid use.
  • Age of user because old age persons possess high sensitivity.
  • The specific medical condition of the user
  • Dosage of administration
  • Mode of administration (Oral, IM, IV)

Administration through the oral route requires from half an hour up to one hour to show effects. Note that following the product label, when you administer it orally, it reaches its peak concentration in blood in up to 60 minutes.

You can feel the effects more quickly if you administer it intravenously. Morphine also comes with an extended-release formulation, meaning it will take longer to reach its peak than normal. In general conditions, medical practitioners administer Morphine in low doses and then increase it until it is well managed.

You should advise Morphine to a person who has never used opioids ever before. Such kind of person needs some time to build up opioid tolerance. Furthermore, you should not select your morphine dose according to your mind.

What Are The Side Effects Of Morphine?

Remember that Morphine has several side effects along with its pain relief function. The typical effects of Morphine may show long-term and short-term effects:

Short-Term Effects Of Morphine

These are some short-term effects of Morphine:

Pain control

Morphine is effective in relieving acute to chronic pain.


Euphoria is a term used to explain feelings of intense pleasure, and Morphine is also involved in causing euphoria in patients.


Morphine is also responsible for causing a sense of relaxation and calmness in patients.

Slowed breathing

Morphine is also involved in causing slowed breathing, and it is life-threatening if you take it in high doses or misuse it.


Morphine is also involved in causing drowsiness and sedation.

Long-Term Effects Of Morphine

Several long-term effects can cause life-threatening situation and mainly includes:


With the increase in patient tolerance, the time to show effects increases, and as a result, you have to administer a high dose of Morphine to get the desired therapeutic effects.

Physical dependence

You must know that you may be physically dependent on Morphine if you regularly use it. In addition, it can cause withdrawal symptoms if you suddenly stop using Morphine.

Morphine addiction

Due to opioid use disorders, this drug is highly addictive, and its long-term adverse effects include habitual drug-seeking behaviors and drug craving.

Respiratory problems

Difficulty breathing and respiratory depression mainly occur with using Morphine for a long duration.

How Long Does Morphine Stay In Your System?

Before discussing the time morphine stays in your body system, you must know that morphine metabolites stay in your body even if there is no feeling of the drug’s effects.

It would help if you considered the test’s sensitivity for people going for morphine drug testing. Remember, the higher the quality of the test, the higher it will show positive results. However, high-sensitivity tests may also produce false results.


The typical blood test for Morphine shows negative much more quickly than any other test. The reason behind this is that Morphine reaches its peak concentration in blood in just one hour of use.

The human body rapidly metabolizes the drug, and it takes about 1 to 4.5 hours to metabolize half of it.


Morphine leaves urine much more rapidly. It depends on:

  • Amount of last dose
  • Person’s metabolism
  • The water consumption of the patient

From the trusted sources, it is concluded that this drug test shows a negative result for about 12 to 36 hours. You can easily detect Morphine from a person’s urine because urine sample tests are too sensitive, and some false positives are also possible.

Breast Milk

You will be surprised to know that Morphine can enter breast milk, and its time to stay in your system will depend on the dosage of Morphine you administer. The typical half of Morphine in breast milk is about half an hour. Still, it reaches its peak concentration in mothers who receive Morphine in epidural space.

Morphine typically stays in breast milk for about one day; after that, you cannot detect it. Breastfeeding mothers must consult a healthcare worker before taking Morphine.


Morphine stays in the user’s hair for a longer period than normal. As you know, in humans, hairs grow rapidly, and older ones are replaced by new ones, so we can conclude that older hair samples show morphine presence and new hair samples will not show morphine presence.

You can find Morphine in your hair for about 90 days after the person has stopped using it.

Withdrawal Of Morphine

The ordinary withdrawal time of Morphine depends on these factors:

A person has restricted morphine usage suddenly or gradually.

The frequency of morphine use

The last dose of Morphine

The ordinary withdrawal symptoms of Morphine appear when the time reaches for the next dose. In addition, symptoms become severe after a few hours.

The withdrawal symptoms reach its peak within a few days. After this period, withdrawal symptoms improved, but the drug craving lasted for a few hours.

Which Factors Are Responsible For The Time Of Morphine To Stay In Your System?

Many factors are responsible for how long Morphine stays in your system, which include:

  • Age
  • Weight
  • Body fat concentration
  • Metabolism of body
  • Kidney and liver function
  • Time from which you are taking Morphine
  • Use of any opioid before Morphine
  • Dosage of Morphine
  • Any medical condition you suffer from
  • Other medications you’re regularly using
  • Alcohol
  • Genetic factors

A person with typical alcohol consumption will have to face more effects of Morphine compared to normal. The user may face life-threatening adverse effects if he combines Morphine with alcohol.

These are some forms of Morphine. If you administer Morphine in this form, it will lead to increased drug release in the body:

  • Taking cut
  • Broken
  • Chewed
  • Crushed
  • Dissolved forms of Morphine.

Medicines That Are Responsible For Increased Effects Of Morphine In A Person’s Body:

You must inform your medical worker if you are using this medicine because these are responsible for the increased effects of Morphine:

  • Opioid drugs like heroin, methadone, and oxycodone
  • CNS depressants, which mainly include diazepam, alprazolam, and alcohol
  • Antidepressants like selegiline, isocarboxazid, phenelzine, tranylcypromine
  • Antihistamines
  • Cimetidine
  • P-glycoprotein (P-gp) inhibitors, like quinidine

Conclusion: How long does Morphine stay in your system?

Morphine is a well-known opioid used to treat acute or chronic pain. How long does Morphine stay in your system? It depends on the amount of dose administered. It typically stays in your system for about 24 hours. But it stays in blood, urine, and breast milk at different times. Last, medicine intake, age, gender, and certain medical conditions affect the time stays of drugs in the body system.

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